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John Parkinson

PhD

Senior Scientist, Molecular Structure and Function, Hospital for Sick Children

Emplacement

Toronto, Ontario

Mots clés

Bioinformatics, Apicomplexa, Toxoplasma, Echinococcus, Genomics, Systems Biology, Metabolism

Recherche d'intérêts

My lab's research interests focus on using genomics-type datasets to understand the evolution and function of the molecular innovations that parasites have acquired to infect and persist within their hosts. Particular emphasis is placed on apicomplexans (Toxoplasma), as well as cestodes (Echinococcus). Our current interests center on the application of systems biology tools to study the organization and operation of metabolic processes within these parasites.

Publications pertinentes

Echinococcosis
Genomics
Toxoplasmosis

Publications pertinentes

Kono, M., Herrmann, S., Loughran, N.B., Cabrera, A., Engelberg, K., Lehmann, C., Sinha, D., Prinz, B., Ruch, U., Heussler, V., Spielman, T., Parkinson, J.* and Gilberger, T.* (2012) Evolutuion and architecture of the inner membrane complex in the asexual and sexual stages of the malaria parasite. Mol. Biol. Evol. In press. DOI: 10.1093/molbev/mss081. *co-corresponding authors


Reid, A.J., Vermont, S.J., Cotton, J.A., Harris, D., Hill-Cawthorne, G.A., Könen-Waisman, S., Latham, S., Mourier, T., Norton, R., et al. (2012) Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy. PLoS Pathogens. In press.


Hung, S. and Parkinson, J. (2011) Post-genomics Resources and Tools for Studying Apicomplexan Metabolism. Trends in Parasitology. 27(3):131-40.


Wasmuth, J., Daub, J., Peregrin-Alvarez, J.M.,Finney, C.A.M. and Parkinson, J. (2009) The origins of apicomplexan sequence innovation. Genome Research. 19:1202-1213.


González, S., Fló, M., Margenat, M., Durán, R., González-Sapienza, G., Graña, M., Parkinson, J., Maizels, R., Salinas, G., Alvarez, B. and Fernandez, C. (2009) A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk. PLoS ONE. 4: e7009.


Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J.E., Delcher, A.L., Guiliano, D.B., Miranda-Saavedra, D., Angiuoli, S.V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N.M., Wortman, J.R., Feldblyum, T., Tallon, L., et al. (2007) Draft genome of the filarial nematode parasite Brugia malayi. Science. 317(5845):1756-60.

Contacter

555 University Avenue

Toronto, ON M5G 1X8

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